Robert N Lightowlers : rechercher sur Z-Library

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Articles (128)
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Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

Craven, Lyndsey, Tuppen, Helen A., Greggains, Gareth D., Harbottle, Stephen J., Murphy, Julie L., Cree, Lynsey M., Murdoch, Alison P., Chinnery, Patrick F., Taylor, Robert W., Lightowlers, Robert N.

Journal:

Nature

Année:

2010

Langue:

english

Fichier:

PDF, 451 KB

english, 2010

What causes mitochondrial DNA deletions in human cells?

Krishnan, Kim J, Reeve, Amy K, Samuels, David C, Chinnery, Patrick F, Blackwood, John K, Taylor, Robert W, Wanrooij, Sjoerd, Spelbrink, Johannes N, Lightowlers, Robert N, Turnbull, Doug M

Journal:

Nature Genetics

Année:

2008

Langue:

english

Fichier:

PDF, 644 KB

english, 2008

Mammalian mitochondrial genetics: heredity, heteroplasmy and disease

Robert N. Lightowlers, Patrick F. Chinnery, Douglass M. Turnbull, Neil Howell

Journal:

Trends in Genetics

Année:

1997

Langue:

english

Fichier:

PDF, 791 KB

english, 1997

Mitochondrial protein synthesis: Figuring the fundamentals, complexities and complications, of mammalian mitochondrial translation

Lightowlers, Robert N., Rozanska, Agata, Chrzanowska-Lightowlers, Zofia M.

Journal:

FEBS Letters

Année:

2014

Langue:

english

Fichier:

PDF, 855 KB

english, 2014

The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease

Elson, Joanna L., Smith, Paul M., Greaves, Laura C., Lightowlers, Robert N., Chrzanowska-Lightowlers, Zofia M.A., Taylor, Robert W., Vila-Sanjurjo, Antón

Journal:

Mitochondrion

Année:

2015

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2015

Mitochondrial Diseases: Hope for the Future

Russell, Oliver M., Gorman, GrÃ¡inne S., Lightowlers, Robert N., Turnbull, Doug M.

Journal:

Cell

Année:

2020

Langue:

english

Fichier:

PDF, 2.68 MB

english, 2020

Nonrandom tissue distribution of mutant mtDNA

Chinnery, Patrick F., Zwijnenburg, Petra J.G., Walker, Mark, Howell, Neil, Taylor, Robert W., Lightowlers, Robert N., Bindoff, Laurence, Turnbull, Douglass M.

Journal:

American Journal of Medical Genetics

Année:

1999

Langue:

english

Fichier:

PDF, 201 KB

english, 1999

Molecular analysis of cytochromec Oxidase deficiency in Leigh's syndrome

Paula L. Adams, Robert N. Lightowlers, Dr. Douglass M. Turnbull

Journal:

Annals of Neurology

Année:

1997

Langue:

english

Fichier:

PDF, 324 KB

english, 1997

Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle

Elizabeth J. Brierley, Margaret A. Johnson, Robert N. Lightowlers, Oliver F. W. James, Dr Douglass M. Turnbull

Journal:

Annals of Neurology

Année:

1998

Langue:

english

Fichier:

PDF, 1.16 MB

english, 1998

Could successful (mitochondrial) networking help prevent Huntington's disease?

Jorge M. A. Oliveira, Robert N. Lightowlers

Journal:

EMBO Molecular Medicine

Année:

2010

Langue:

english

Fichier:

PDF, 256 KB

english, 2010

Specific targeting of a DNA-alkylating reagent to mitochondria : Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide

Andrew M. James, Frances H. Blaikie, Robin A. J. Smith, Robert N. Lightowlers, Paul M. Smith, Michael P. Murphy

Journal:

FEBS Journal

Année:

2003

Langue:

english

Fichier:

PDF, 330 KB

english, 2003

Myb Controls Intestinal Stem Cell Genes and Self-Renewal

Dane Cheasley, Lloyd Pereira, Sally Lightowler, Elizabeth Vincan, Jordane Malaterre, Robert G. Ramsay

Journal:

STEM CELLS

Année:

2011

Langue:

english

Fichier:

PDF, 3.03 MB

english, 2011

A low-temperature-responsive gene from barley encodes a protein with single-stranded nucleic acid-binding activity which is phosphorylatedin vitro

M. Alison Dunn, Kate Brown, Robert Lightowlers, Monica A. Hughes

Journal:

Plant Molecular Biology

Année:

1996

Langue:

english

Fichier:

PDF, 1.28 MB

english, 1996

Altering the balance between healthy and mutated mitochondrial DNA

Paul M. Smith, Robert N. Lightowlers

Journal:

Journal of Inherited Metabolic Disease

Année:

2011

Langue:

english

Fichier:

PDF, 124 KB

english, 2011

DNA Delivery to Mitochondria: Sequence Specificity and Energy Enhancement

Noha Ibrahim, Hirokazu Handa, Anne Cosset, Milana Koulintchenko, Yuri Konstantinov, Robert N. Lightowlers, André Dietrich, Frédérique Weber-Lotfi

Journal:

Pharmaceutical Research

Année:

2011

Langue:

english

Fichier:

PDF, 488 KB

english, 2011

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

Marco Nooteboom, Riem Johnson, Robert W. Taylor, Nicholas A. Wright, Robert N. Lightowlers, Thomas B. L. Kirkwood, John C. Mathers, Doug M. Turnbull, Laura C. Greaves

Journal:

Aging Cell

Année:

2010

Langue:

english

Fichier:

PDF, 302 KB

english, 2010

10.1038/13779

Turnbull, Douglass M., Andrews, Richard M., Kubacka, Iwona, Chinnery, Patrick F., Lightowlers, Robert N., Howell, Neil

Journal:

Nature Genetics

Année:

1999

Langue:

english

Fichier:

PDF, 70 KB

english, 1999

10.1038/90929

Turnbull, Douglass M., Lightowlers, Robert N.

Journal:

Nature Medicine

Année:

2001

Langue:

english

Fichier:

PDF, 145 KB

english, 2001

A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome

Richter, Ricarda, Rorbach, Joanna, Pajak, Aleksandra, Smith, Paul M, Wessels, Hans J, Huynen, Martijn A, Smeitink, Jan A, Lightowlers, Robert N, Chrzanowska-Lightowlers, Zofia M

Journal:

The EMBO Journal

Année:

2010

Langue:

english

Fichier:

PDF, 1.32 MB

english, 2010

Mitochondrial transformation: time for concerted action

Lightowlers, Robert N

Journal:

EMBO reports

Année:

2011

Langue:

english

Fichier:

PDF, 68 KB

english, 2011

Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids

Taylor, Robert W., Chinnery, Patrick F., Turnbull, Douglass M., Lightowlers, Robert N.

Journal:

Nature Genetics

Année:

1997

Fichier:

PDF, 665 KB

1997

An essential guide to mtDNA maintenance

Turnbull, Doug M., Lightowlers, Robert N.

Journal:

Nature Genetics

Année:

1998

Fichier:

PDF, 322 KB

1998

A roundabout route to gene therapy

Turnbull, Douglass M., Lightowlers, Robert N.

Journal:

Nature Genetics

Année:

2002

Langue:

english

Fichier:

PDF, 505 KB

english, 2002

Reversal of a mitochondrial DNA defect in human skeletal muscle

Clark, Kim M., Bindoff, Laurence A., Lightowlers, Robert N., Andrews, Richard M., Griffiths, Philip G., Johnson, Margaret A., Brierley, Elizabeth J., Turnbull, Douglass M.

Journal:

Nature Genetics

Année:

1997

Fichier:

PDF, 412 KB

1997

Multiple neonatal deaths due to a homoplasmic mitochondrial DNA mutation

McFarland, Robert, Clark, Kim M., Morris, Andrew A.M., Taylor, Robert W., Macphail, Sheila, Lightowlers, Robert N., Turnbull, Douglass M.

Journal:

Nature Genetics

Année:

2002

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2002

A novel point mutation in the mitochondrial tRNATrp gene produces a neurogastrointestinal syndrome

Maniura-Weber, Katharina, Taylor, Robert W, Johnson, Margaret A, Chrzanowska-Lightowlers, Zofia, Morris, Andrew A M, Charlton, Charles P J, Turnbull, Douglass M, Bindoff, Laurence A

Journal:

European Journal of Human Genetics

Année:

2004

Langue:

english

Fichier:

PDF, 125 KB

english, 2004

Treatment of Mitochondrial Disease

Robert W. Taylor, Patrick F. Chinnery, Kim M. Clark, Robert N. Lightowlers, Douglass M. Turnbull

Journal:

Journal of Bioenergetics and Biomembranes

Année:

1997

Langue:

english

Fichier:

PDF, 1.12 MB

english, 1997

Neuropathological Aspects of Mitochondrial DNA Disease

Joanne Betts, Robert N. Lightowlers, Douglass M. Turnbull

Journal:

Neurochemical Research

Année:

2004

Langue:

english

Fichier:

PDF, 70 KB

english, 2004

Phage display selection of efficient glutamine-donor substrate peptides for transglutaminase 2

Zsolt Keresztessy, Éva Csősz, Jolán Hársfalvi, Krisztián Csomós, Joe Gray, Robert N. Lightowlers, Jeremy H. Lakey, Zoltán Balajthy, László Fésüs

Journal:

Protein Science

Année:

2006

Langue:

english

Fichier:

PDF, 676 KB

english, 2006

Isolation of a cDNA specifying subunit VIIb of human cytochrome c oxidase

James E. Sadlock, Robert N. Lightowlers, Roderick A. Capaldi, Eric A. Schon

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Année:

1993

Langue:

english

Fichier:

PDF, 266 KB

english, 1993

Developing a genetic approach to investigate the mechanism of mitochondrial competence for DNA import

Frédérique Weber-Lotfi, Noha Ibrahim, Pierre Boesch, Anne Cosset, Yuri Konstantinov, Robert N. Lightowlers, André Dietrich

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Année:

2009

Langue:

english

Fichier:

PDF, 797 KB

english, 2009

Human mitochondrial mRNAs—like members of all families, similar but different

Richard J. Temperley, Mateusz Wydro, Robert N. Lightowlers, Zofia M. Chrzanowska-Lightowlers

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Année:

2010

Langue:

english

Fichier:

PDF, 373 KB

english, 2010

Knowing when to stop — human mitochondrial translation termination

Ricarda Richter, Aleksandra Pajak, Sven Dennerlein, Paul M. Smith, Agata Rozanska, Robert N. Lightowlers, Zofia M.A. Chrzanowska-Lightowlers

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Année:

2010

Langue:

english

Fichier:

PDF, 117 KB

english, 2010

Bridging PNAs can bind preferentially to a deleted mitochondrial DNA template but replication by mitochondrial DNA polymerase γ in vitro is not impaired

Alistair McGregor, Paul M. Smith, Günther F. Ross, Robert W. Taylor, Douglass M. Turnbull, Robert N. Lightowlers

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Année:

2003

Langue:

english

Fichier:

PDF, 580 KB

english, 2003

Maintenance and stabilization of mtDNA can be facilitated by the DNA-binding activity of Ilv5p

Malgorzata Macierzanka, Magdalena Plotka, Diana Pryputniewicz-Drobinska, Agnieszka Lewandowska, Robert Lightowlers, Jaroslaw Marszalek

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

2008

Langue:

english

Fichier:

PDF, 1.22 MB

english, 2008

DNA repair in organelles: Pathways, organization, regulation, relevance in disease and aging

Pierre Boesch, Frédérique Weber-Lotfi, Noha Ibrahim, Vladislav Tarasenko, Anne Cosset, François Paulus, Robert N. Lightowlers, André Dietrich

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

2011

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2011

Taenia solium and Taenia ovis: Stage-specific expression of the vaccine antigen genes, TSOL18, TSOL16, and homologues, in oncospheres

Charles G. Gauci, Manuela R. Verástegui, Robert H. Gilman, Marshall W. Lightowlers

Journal:

Experimental Parasitology

Année:

2006

Langue:

english

Fichier:

PDF, 335 KB

english, 2006

Probing the orientation of yeast VDAC1 in vivo

Beth M. McDonald, Mateusz M. Wydro, Robert N. Lightowlers, Jeremy H. Lakey

Journal:

FEBS Letters

Année:

2009

Langue:

english

Fichier:

PDF, 500 KB

english, 2009

Mitochondrial transfection for studying organellar DNA repair, genome maintenance and aging

Daria Mileshina, Noha Ibrahim, Pierre Boesch, Robert N. Lightowlers, André Dietrich, Frédérique Weber-Lotfi

Journal:

Mechanisms of Ageing and Development

Année:

2011

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2011

Messenger RNA stability in mitochondria: different means to an end

Dominique Gagliardi, Piotr P Stepien, Richard J Temperley, Robert N Lightowlers, Zofia M.A Chrzanowska-Lightowlers

Journal:

Trends in Genetics

Année:

2004

Langue:

english

Fichier:

PDF, 586 KB

english, 2004

Mitochondrial DNA clonality in the dock: can surveillance swing the case?

Joanna L. Elson, Robert N. Lightowlers

Journal:

Trends in Genetics

Année:

2006

Langue:

english

Fichier:

PDF, 296 KB

english, 2006

A high frequency of mtDNA polymorphisms in HeLa cell sublines

Corinna Herrnstadt, Gwen Preston, Richard Andrews, Patrick Chinnery, Robert N. Lightowlers, Douglass M. Turnbull, Iwona Kubacka, Neil Howell

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

2002

Langue:

english

Fichier:

PDF, 190 KB

english, 2002

Changes in the human mitochondrial genome after treatment of malignant disease

Theresa M Wardell, Elaine Ferguson, Patrick F Chinnery, Gillian M Borthwick, Robert W Taylor, Graham Jackson, Alan Craft, Robert N Lightowlers, Neil Howell, Douglass M Turnbull

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

2003

Langue:

english

Fichier:

PDF, 98 KB

english, 2003

The inheritance of mitochondrial DNA heteroplasmy: random drift, selection or both?

Patrick F Chinnery, David R Thorburn, David C Samuels, Sarah L White, Hans-Heinrik M Dahl, Doug M Turnbull, Robert N Lightowlers, Neil Howell

Journal:

Trends in Genetics

Année:

2000

Langue:

english

Fichier:

PDF, 209 KB

english, 2000

Human mitochondria: distinct organelles or dynamic network?

Thomas Preiss, Shelagh A. Lowerson, Katharina Weber, Robert N. Lightowlers

Journal:

Trends in Genetics

Année:

1995

Langue:

english

Fichier:

PDF, 375 KB

english, 1995

Mitochondrial DNA – all things bad?

Robert N Lightowlers, Howard T Jacobs, Olli A Kajander

Journal:

Trends in Genetics

Année:

1999

Langue:

english

Fichier:

PDF, 384 KB

english, 1999

Targeting large molecules to mitochondria

Aleksandra Muratovska, Robert N Lightowlers, Robert W Taylor, Jacqueline A Wilce, Michael P Murphy

Journal:

Advanced Drug Delivery Reviews

Année:

2001

Langue:

english

Fichier:

PDF, 1.67 MB

english, 2001

An antigenomic strategy for treating heteroplasmic mtDNA disorders

Robert W. Taylor, Theresa M. Wardell, Paul M. Smith, Aleksandra Muratovska, Michael P. Murphy, Douglass M. Turnbull, Robert N. Lightowlers

Journal:

Advanced Drug Delivery Reviews

Année:

2001

Langue:

english

Fichier:

PDF, 184 KB

english, 2001

Glutamate dehydrogenase: an organelle-specific mRNA-binding protein

Thomas Preiss, Zofia M. Chrzanowska-Lightowlers, Robert N. Lightowlers

Journal:

Trends in Biochemical Sciences

Année:

1997

Langue:

english

Fichier:

PDF, 306 KB

english, 1997

Identification of the NAD+-Binding Fold of Glyceraldehyde-3-Phosphate Dehydrogenase as a Novel RNA-Binding Domain

Eszter Nagy, Tamás Henics, Mária Eckert, Attila Miseta, Robert N. Lightowlers, Miklós Kellermayer

Journal:

Biochemical and Biophysical Research Communications

Année:

2000

Langue:

english

Fichier:

PDF, 212 KB

english, 2000